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비쥬얼

The Secrets of Caledonia

The Secrets of Caledonia (TSOC) is a supplier of natural cosmetic ingredients inspired by Scottish traditional herbal medicine.
Taking advantage of Scotland’s biodiversity and working in collaboration with established Scottish herbalists,
we aim to provide the most effective and innovative natural ingredients at the highest quality.

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Product

English Chamomile Extract-SC
INCI name_ Anthemis Nobilis Flower Extract
Roman Chamomile, also called English Chamomile, is a low growing evergreen  perennial herb found in the wild and cultivated
habitats in Western Europe. It is now grown all around the world in different temperate regions. Some sources show the Romans
were the first to cultivate chamomile on a large scale in the 16th century while others give credit to botanists from Great Britain.
The plant forms a spreading mat of aromatic foliage and daisy-like flowers with white rays and yellow centers.
The use of chamomile flower heads has been documented as far back as the ancient Egyptian, it is considered to be antiseptic,
antibiotic, disinfectant, bactericidal, fungicidal and anthelmintic. It has been used for centuries as anti-inflammatory, antioxidant,
mild astringent, mild sedative, antispasmodic, antibacterial and healing medicine. External applications of extracts and lotions are
recommended as repellent, emollient, in the treatment of skin disorders and to promote youthful appearance. Chamomile flower
tea was used as a tranquilizer and to promote longevity.
Studies of Roman chamomile flower extracts showed that both lipophilic and hydrophilic compounds take part in its therapeutic
activity. The most characteristic constituents of this plant species are volatile oil, sesquiterpene lactones and phenolics including
flavonoids. The flower heads of Roman Chamomile also contain polyphenols, flavonoids and alkaloids as caffeic acid.
Our tests on Chamomile flower extract demonstrated :antioxidant and anti-allergy efficacies. 

 


Figure 1 


figure 01.png


- Increase in English chamomile extract concentration is directly proportional to its DPPH radical scavenging activity 


- Radical scavenging activity expressed as SC50, which represents the concentration of the extract (v/v%) required to inhibit 50%
of the free DPPH radical 


- Low SC50; 0.71% indicates high radical scavenging activity 


- Significant scavenging activity observed even at low extract concentrations 


- Anti-oxidant properties confirmed 


 


Figure 2 


figure 02.png


- Superoxide dismutase (SOD) is a metalloenzyme that catalyses the dismutation of superoxide radical into hydrogen peroxide and
molecular oxygen 


- SOD assay was used to determine if English chamomile extract stimulated the enzyme activity. Trolox (vitamin E analogue), a
well-known antioxidant compound was used as positive control. 


- Elevated SOD superoxide scavenging activity was observed at high extract concentrations 


- Low SC50 value indicating high scavenging activity 


- Antioxidant properties of English Chamomile confirmed 


 


 Figure 3 


figure 03.png


- An allergic response is a hypersensitive immune reaction to a harmless substance, causing conditions such as dermatitis, rash and
itching on skin 


- Mast cells are regulators of the immune system, they contain biologically active granules (mediators)which are secreted when
they are triggered, a process called degranulation 


- Beta-hexosaminidase is a marker for the granules that contain allergic mediators in mast cells 


- Its release indicates mast cells degranulation 


- English Chamomile extract showed beta-hexosaminidase release inhibition in a concentration-dependent manner 


- Anti-allergy properties of English Chamomile extract is confirmed